Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

E.      Kerouredan; M.      Prakesch; D.      Gree; R.      Gree

doi:10.2174/1570178043488662

Author(s): E. Kerouredan, M. Prakesch, D. Gree and R. Gree

Volume 1, Issue 1, 2004

Page: [78 - 80] Pages: 3

DOI: 10.2174/1570178043488662

Abstract

The first total synthesis of the 13,13 difluoro analog of 13 HODE, via the novel fluorinated synthons (5) and (2), is reported. The key advantages of using a propargylic route for the introduction of the gem difluoro moiety are highlighted below.

Keywords: fluorine, dast, 13 hode, lipids

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Letters in Organic Chemistry

Title: Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

Volume: 1 Issue: 1

Author(s): E. Kerouredan, M. Prakesch, D. Gree and R. Gree

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Keywords: fluorine, dast, 13 hode, lipids

Abstract: The first total synthesis of the 13,13 difluoro analog of 13 HODE, via the novel fluorinated synthons (5) and (2), is reported. The key advantages of using a propargylic route for the introduction of the gem difluoro moiety are highlighted below.

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Kerouredan E., Prakesch M., Gree D. and Gree R., Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488662