Synthesis of New Ligands Derived from Polyphosphonates Partial Esters

Title: Synthesis of New Ligands Derived from Polyphosphonates Partial Esters

Volume: 1 Issue: 1

Author(s): Pascale Even, Erwann Guenin, Mounya Benramdame, Patricia Quidu, Driss El Manouni and Marc Lecouvey

Affiliation:

Keywords: tetraphosphonate, chelating agents, restrained geometry, partial deprotection

Abstract: In the search for new chelation therapy drugs for the treatment of metal intoxications, some new polyphosphonated chelating ligands have been synthesized. They were obtained by means of an Arbuzov reaction followed by addition of the corresponding dialkylphosphite. The regioselective dealkylation was then carried out by using trimethylsilyl halide.

Cite this article as:

Even Pascale, Guenin Erwann, Benramdame Mounya, Quidu Patricia, Manouni El Driss and Lecouvey Marc, Synthesis of New Ligands Derived from Polyphosphonates Partial Esters, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488563