Pharmacogenomics: The Influence of Genomic Variation on Drug Response

Title: Pharmacogenomics: The Influence of Genomic Variation on Drug Response

Volume: 4 Issue: 13

Author(s): Fabienne J. Thomas, Howard L. McLeod and James W. Watters

Affiliation:

Keywords: pharmacogenomics, pharmacogenetics, drug therapy, snp.

Abstract: Unpredictable efficacy and toxicity are major hurdles in the administration of many medications. By identifying inherited DNA polymorphisms that influence drug disposition and effects, pharmacogenomics is an exciting tool for the individualization of drug therapies. Single nucleotide polymorphisms (SNP) in genes encoding drug metabolizing enzymes, drug transporters, and DNA repair genes have recently been shown to influence drug toxicity and efficacy. This review will discuss clinically relevant examples of genetic polymorphisms that influence the outcome of drug therapy, and possibilities for future applications of pharmacogenomics.

Cite this article as:

Thomas J. Fabienne, McLeod L. Howard and Watters W. James, Pharmacogenomics: The Influence of Genomic Variation on Drug Response, Current Topics in Medicinal Chemistry 2004; 4 (13) . https://dx.doi.org/10.2174/1568026043387638