Genetics of Ribosome-Inactivating Proteins

Title: Genetics of Ribosome-Inactivating Proteins

Volume: 4 Issue: 5

Author(s): Martin R. Hartley and J. Michael Lord

Affiliation:

Keywords: ribosome-inactivating protein, ricin, pokeweed antiviral protein, rna n-glycosidase

Abstract: Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They encompass single enzymatic chains, heterodimeric toxic lectins and related agglutinins. Plants commonly produce several RIP isoforms encoded by multi-gene families. The toxic lectins possess adaptations related to their cytotoxic role.

Cite this article as:

Hartley R. Martin and Lord Michael J., Genetics of Ribosome-Inactivating Proteins, Mini-Reviews in Medicinal Chemistry 2004; 4 (5) . https://dx.doi.org/10.2174/1389557043403828