Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules

Damiano      Banfi; Manfred      Mutter; Luc      Patiny

doi:10.2174/0929866043406274

Abstract

This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Bochydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis.

Keywords: chemoselective ligation, template assembled synthetic proteins (tasp), n-boc-3-(4-cyanophenyl)oxaziridine (bpco), synthesis, amino acids, electrophilic amino group

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Protein & Peptide Letters

Title: Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules

Volume: 11 Issue: 6

Author(s): Damiano Banfi, Manfred Mutter and Luc Patiny

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Keywords: chemoselective ligation, template assembled synthetic proteins (tasp), n-boc-3-(4-cyanophenyl)oxaziridine (bpco), synthesis, amino acids, electrophilic amino group

Abstract: This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Bochydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis.

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Banfi Damiano, Mutter Manfred and Patiny Luc, Versatile Synthesis of Boc Protected Hydrazinoacetic Acid and its Application to the Chemoselective Ligation of Tasp Molecules, Protein & Peptide Letters 2004; 11 (6) . https://dx.doi.org/10.2174/0929866043406274