Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists

Marlon      Cowart; Robert      Altenbach; Lawrence      Black; Ramin      Faghih; Chen      Zhao; Arthur   A.   Hancock

doi:10.2174/1389557043403215

Abstract

The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

Keywords: non-nimidazole, histamine, h3, review, antagonist, inverse agonist

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Mini-Reviews in Medicinal Chemistry

Title: Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists

Volume: 4 Issue: 9

Author(s): Marlon Cowart, Robert Altenbach, Lawrence Black, Ramin Faghih, Chen Zhao and Arthur A. Hancock

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Keywords: non-nimidazole, histamine, h3, review, antagonist, inverse agonist

Abstract: The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

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Cowart Marlon, Altenbach Robert, Black Lawrence, Faghih Ramin, Zhao Chen and Hancock A. Arthur, Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403215