Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists

Title: Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists

Volume: 4 Issue: 9

Author(s): Holger Stark, Markus Kathmann, Eberhard Schlicker, Walter Schunack, Birgit Schlegel and Wolfgang Sippl

Affiliation:

Keywords: cipralisant, ciproxifan, clobenpropit, h3 receptor, imidazole, sch 79687, radioligand, thioperamide

Abstract: The first antagonists known for the histamine H3 receptor were mono-substituted imidazolecontaining compounds like thioperamide. Meanwhile numerous novel leads have been developed possessing improved affinities, selectivities, specificities, and pharmacokinetic properties. Scope and limitations of this promising class are discussed concerning their structure-activity relationships as well as pharmacological and potential therapeutic aspects.

Cite this article as:

Stark Holger, Kathmann Markus, Schlicker Eberhard, Schunack Walter, Schlegel Birgit and Sippl Wolfgang, Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403107