Histamine H3 Receptor Agonists

I.   J.P.   De Esch; K.   J.   Belzar

doi:10.2174/1389557043403134

Abstract

The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

Keywords: histamine, h3, gpcr, agonist, isoform, activity, efficacy, affinity

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Mini-Reviews in Medicinal Chemistry

Title: Histamine H3 Receptor Agonists

Volume: 4 Issue: 9

Author(s): I. J.P. De Esch and K. J. Belzar

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Keywords: histamine, h3, gpcr, agonist, isoform, activity, efficacy, affinity

Abstract: The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.

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De Esch J.P. I. and Belzar J. K., Histamine H3 Receptor Agonists, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403134