The Relationship Between Inhibitors of Eukaryotic and Prokaryotic Serine Proteases

Title: The Relationship Between Inhibitors of Eukaryotic and Prokaryotic Serine Proteases

Volume: 4 Issue: 7

Author(s): Monika I. Konaklieva and Balbina J. Plotkin

Affiliation:

Keywords: serine proteases, lactamases, human leukocyte elastase, serine protease inhibitors

Abstract: The ability to inhibit serine proteases is a major focus in the pharmaceutical industry. Serine proteases of medical importance range in phylogenetic diversity from the metallo-proteases, which play a role in pulmonary hypertension, and destruction of the lung parenchyma in emphysema, to those proteases (betalactamases), which play a role in the resistance of bacteria to beta-lactam antibiotics. In both the mammalian and microbial systems, the development of serine protease inhibitors has been a focal strategy spurring investigations in the area of serine protease dependent prodrugs that incorporate a bactericidal moiety as well as other classes of metalloprotease inhibitors.

Cite this article as:

Konaklieva I. Monika and Plotkin J. Balbina, The Relationship Between Inhibitors of Eukaryotic and Prokaryotic Serine Proteases, Mini-Reviews in Medicinal Chemistry 2004; 4 (7) . https://dx.doi.org/10.2174/1389557043403611