Novel Treatments of Schizophrenia: Targeting the Neurotensin System

Title: Novel Treatments of Schizophrenia: Targeting the Neurotensin System

Volume: 5 Issue: 2

Author(s): B. Kinkead and C. B. Nemeroff

Affiliation:

Keywords: Antipsychotic drug, peptide, neuromedin N, xenin, schizophrenia

Abstract: Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.

Cite this article as:

Kinkead B. and Nemeroff B. C., Novel Treatments of Schizophrenia: Targeting the Neurotensin System, CNS & Neurological Disorders - Drug Targets 2006; 5 (2) . https://dx.doi.org/10.2174/187152706776359655