Toward the Synthesis of Reidispongiolide A: An Improved Stereocontrolled Synthesis of the C23-C35 Fragment of Reidispongiolide A

Title: Toward the Synthesis of Reidispongiolide A: An Improved Stereocontrolled Synthesis of the C23-C35 Fragment of Reidispongiolide A

Volume: 1 Issue: 4

Author(s): Angela Zampella, Valentina Sepe, Rosa D'Orsi and Maria Valeria D'Auria

Affiliation:

Keywords: reidispongiolide, antitumoral macrolides, asymmetric synthesis, diastereoselectivity, crotylboration

Abstract: An improved synthesis of the C23-C35 moiety of reidispongiolide A has been completed. An intermolecular Nozaki-Hiyama-Kishi coupling was employed for the union of C23-C30 and C31-C35 fragments. A discussion on the factors influencing the stereochemical outcome of (E)-crotylboration reactions of α-methyl-βl-alkoxy aldehydes is also presented.

Cite this article as:

Zampella Angela, Sepe Valentina, D'Orsi Rosa and D'Auria Valeria Maria, Toward the Synthesis of Reidispongiolide A: An Improved Stereocontrolled Synthesis of the C23-C35 Fragment of Reidispongiolide A, Letters in Organic Chemistry 2004; 1 (4) . https://dx.doi.org/10.2174/1570178043400523