First and Second Generations of COX-2 Selective Inhibitors

Title: First and Second Generations of COX-2 Selective Inhibitors

Volume: 4 Issue: 6

Author(s): Xavier de Leval, Fabien Julemont, Valerie Benoit, Michel Frederich, Bernard Pirotte and Jean-Michel Dogne

Affiliation:

Keywords: cox-2 inhibitors, cox-2 selectivity, pre-clinical data

Abstract: The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.

Cite this article as:

Leval de Xavier, Julemont Fabien, Benoit Valerie, Frederich Michel, Pirotte Bernard and Dogne Jean-Michel, First and Second Generations of COX-2 Selective Inhibitors, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403693