Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity

Title: Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity

Volume: 11 Issue: 4

Author(s): Maria Sakarellos-Daitsiotis, Manh-Thong Cung, Constantinos Sakarellos, Zouhair El Hilali, Aggeliki Kosmopoulou and Chryssa Voitharou

Affiliation:

Keywords: complementary epitopes, autoimmune diseases, anti-idiotypic antibodies

Abstract: Application of complementary B and T cell epitopes in inducing anti-idiotypic and anticlonotypic antibodies capable of regulating or suppressing the autoimmune responses in experimental autoimmune myasthenia gravis (EAMG), allergic neuritis (EAN) and allergic encephalomyelitis (EAE) has been the stimulus of many research efforts. Studies on the idiotypic / anti-idiotypic network of anti-La / SSB positive sera from patients with Sjogrens Syndrome (SS) and Systemic Lupus Erythematosus (SLE) and on animals immunized with the complementary epitopes are presented.

Cite this article as:

Sakarellos-Daitsiotis Maria, Cung Manh-Thong, Sakarellos Constantinos, Hilali El Zouhair, Kosmopoulou Aggeliki and Voitharou Chryssa, Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity, Protein & Peptide Letters 2004; 11 (4) . https://dx.doi.org/10.2174/0929866043407020