The Intracellular Distribution and Secretion of Endopeptidases 24.15 415 (Ec 3.4.24.15) and 24.16 (Ec 3.4.24.16)

Emer   S.   Ferro; Flavia   R.   Carreno; Camila      Goni; Paula   A.G.   Garrido; Alessander   O.   Guimaraes; Leandro   M.   Castro; Vitor      Oliveira; Mauricio   C.   Araujo; Vanessa      Rioli; Marcelo   D.   Gomes; Jose   Domingues   Fontenele-Neto; Stephen      Hyslop

doi:10.2174/0929866043406706

Abstract

Endopeptidase 24.15 (EC 3.4.24.15; EP24.15) and endopeptidase 24.16 (EC 3.4.24.16; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of these homologous enzymes in the central nervous system. These are important issues for a better understanding of the functions of EP24.15 and EP24.16 within neuroendocrine systems.

Keywords: endopeptidase, exocytosis, neurolysin, peptide metabolism, thimet-oligopeptidase, unconventional, secretion, fusion pore

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Protein & Peptide Letters

Title: The Intracellular Distribution and Secretion of Endopeptidases 24.15 415 (Ec 3.4.24.15) and 24.16 (Ec 3.4.24.16)

Volume: 11 Issue: 5

Author(s): Emer S. Ferro, Flavia R. Carreno, Camila Goni, Paula A.G. Garrido, Alessander O. Guimaraes, Leandro M. Castro, Vitor Oliveira, Mauricio C. Araujo, Vanessa Rioli, Marcelo D. Gomes, Jose Domingues Fontenele-Neto and Stephen Hyslop

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Keywords: endopeptidase, exocytosis, neurolysin, peptide metabolism, thimet-oligopeptidase, unconventional, secretion, fusion pore

Abstract: Endopeptidase 24.15 (EC 3.4.24.15; EP24.15) and endopeptidase 24.16 (EC 3.4.24.16; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of these homologous enzymes in the central nervous system. These are important issues for a better understanding of the functions of EP24.15 and EP24.16 within neuroendocrine systems.

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Ferro S. Emer, Carreno R. Flavia, Goni Camila, Garrido A.G. Paula, Guimaraes O. Alessander, Castro M. Leandro, Oliveira Vitor, Araujo C. Mauricio, Rioli Vanessa, Gomes D. Marcelo, Fontenele-Neto Domingues Jose and Hyslop Stephen, The Intracellular Distribution and Secretion of Endopeptidases 24.15 415 (Ec 3.4.24.15) and 24.16 (Ec 3.4.24.16), Protein & Peptide Letters 2004; 11 (5) . https://dx.doi.org/10.2174/0929866043406706