Met-204 And Tyr-205 Are Together Important For Binding Glp-1 Receptor Agonists But Not Their N-Terminally Truncated Analogues

Title: Met-204 And Tyr-205 Are Together Important For Binding Glp-1 Receptor Agonists But Not Their N-Terminally Truncated Analogues

Volume: 11 Issue: 1

Author(s): Rakel Lopez de Maturana, Janet Treece-Birch, Fatima Abidi, John B.C. Findlay and Dan Donnelly

Affiliation:

Keywords: Met-204 And Tyr-205, N-terminally, Glp-1 Receptor

Abstract: A mutagenesis study to systematically analyse residues spanning the first extracellular loop of the GLP-1 receptor identified a double mutant, Met-204 / Tyr-205-Ala / Ala, which displayed: markedly reduced affinity for the natural agonist GLP-1; slightly reduced affinity for its analogue exendin-4; and unaltered affinity for several N-terminally truncated analogues of GLP-1 and exendin-4. This suggests that the locus is important for the formation of the binding site for the N-terminal residues of peptide agonists.

Cite this article as:

de Maturana Lopez Rakel, Treece-Birch Janet, Abidi Fatima, Findlay B.C. John and Donnelly Dan, Met-204 And Tyr-205 Are Together Important For Binding Glp-1 Receptor Agonists But Not Their N-Terminally Truncated Analogues, Protein & Peptide Letters 2004; 11 (1) . https://dx.doi.org/10.2174/0929866043478491