Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery

Title: Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery

Volume: 4 Issue: 3

Author(s): E. ter Haar, W. P. Walters, S. Pazhanisamy, P. Taslimi, A. C. Pierce, G. W. Bemis, F. G. Salituro and S. L. Harbeson

Affiliation:

Keywords: chemogenomics, kinases, structure-based drug design

Abstract: Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPKfamily will be discussed.

Cite this article as:

Haar ter E., Walters P. W., Pazhanisamy S., Taslimi P., Pierce C. A., Bemis W. G., Salituro G. F. and Harbeson L. S., Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery, Mini-Reviews in Medicinal Chemistry 2004; 4 (3) . https://dx.doi.org/10.2174/1389557043487367