Aryloxy Phosphoramidate Triesters as Pro-Tides

Dominique      Cahard; Christopher      McGuigan; Jan      Balzarini

doi:10.2174/1389557043403936

Abstract

We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.

Keywords: nucleotide, pro-drug, phosphoramidate

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Mini-Reviews in Medicinal Chemistry

Title: Aryloxy Phosphoramidate Triesters as Pro-Tides

Volume: 4 Issue: 4

Author(s): Dominique Cahard, Christopher McGuigan and Jan Balzarini

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Keywords: nucleotide, pro-drug, phosphoramidate

Abstract: We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.

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Cahard Dominique, McGuigan Christopher and Balzarini Jan, Aryloxy Phosphoramidate Triesters as Pro-Tides, Mini-Reviews in Medicinal Chemistry 2004; 4 (4) . https://dx.doi.org/10.2174/1389557043403936