The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues

Ashraf   S.   Al-Madhoun; Werner      Tjarks; Staffan      Eriksson

doi:10.2174/1389557043403963

Abstract

Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1 thymidine kinase. Important substrate activity relationships will be discussed.

Keywords: tk1, tk2 dm-dnk, hsv1-tk, nucleoside analogues, chemotherapy, bnct

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Mini-Reviews in Medicinal Chemistry

Title: The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues

Volume: 4 Issue: 4

Author(s): Ashraf S. Al-Madhoun, Werner Tjarks and Staffan Eriksson

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Keywords: tk1, tk2 dm-dnk, hsv1-tk, nucleoside analogues, chemotherapy, bnct

Abstract: Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1 thymidine kinase. Important substrate activity relationships will be discussed.

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Al-Madhoun S. Ashraf, Tjarks Werner and Eriksson Staffan, The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues, Mini-Reviews in Medicinal Chemistry 2004; 4 (4) . https://dx.doi.org/10.2174/1389557043403963