Understanding Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Coinfection

Title: Understanding Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Coinfection

Volume: 4 Issue: 1

Author(s): Yee-Joo Tan, Seng G. Lim and Wanjin Hong

Affiliation:

Keywords: Human immunodeficiency virus type 1, hepatitis C virus, HIV/HCV coinfection, immune evasion, viral-host interactions, quasispecies

Abstract: In recent years, there has been an alarming increase in the number of cases of coinfection with the human immunodeficiency virus type 1 (HIV-1) and the hepatitis C virus (HCV). It is now known that coinfection of HIV-1 patients by HCV can complicate the treatment of these patients with highly active antiretroviral therapy and the interactions between anti-HIV-1 and anti-HCV medications can also affect treatment efficacy and efficiency. Equally concerning, the bidirectional interferences between the two viruses are complex and can modify the natural history of both infections. This review aims to summarize the findings of numerous scientific investigations in the area of HIV/HCV coinfection. These investigations can be broadly classified into 3 groups; (a) immune evasion mechanisms (b) viral evolution and quasispecies diversity and (c) functions of viral proteins and their interactions with host factors. Our cumulative knowledge in this area and future research on the interplay between these two viruses will be important to the development of better antiviral therapeutics.

Cite this article as:

Tan Yee-Joo, Lim G. Seng and Hong Wanjin, Understanding Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Coinfection, Current HIV Research 2006; 4 (1) . https://dx.doi.org/10.2174/157016206775197600