Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch

Title: Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch

Volume: 12 Issue: 4

Author(s): Frank Bosmans, Bert Brone, Yan-Mei Sun, Rong-Huan Zhu, Yu-Mei Xiong, Da-Cheng Wang, Emmy Van Kerkhove and Jan Tytgat

Affiliation:

Keywords: bmkm, voltage-gated na channels, locust dum neurons, para/tipe

Abstract: In this study, the effect of the scorpion a-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.

Cite this article as:

Bosmans Frank, Brone Bert, Sun Yan-Mei, Zhu Rong-Huan, Xiong Yu-Mei, Wang Da-Cheng, Kerkhove Van Emmy and Tytgat Jan, Pharmacological Comparison of Two Different Insect Models Using the Scorpion α-Like Toxin BmK M1 from Buthus martensii Karsch, Protein & Peptide Letters 2005; 12 (4) . https://dx.doi.org/10.2174/0929866053765635