Design and Synthesis of a New Furanosic Sialylmimetic as a Potential Influenza Neuraminidase Viral Inhibitor

A.      Bianco; M.      Brufani; D.   A.   Dri; C.      Melchioni; L.      Filocamo

doi:10.2174/1570178053400207

Abstract

A furanosic derivative has been identified as a simple sialylmimetic and synthesized, representing the first step in the development of a new series of furanosic sialic acids mimetics as potential inhibitors of influenza virus neuraminidase. The structure was tested on a molecular simulating environment before proceeding with synthetic pathways.

Keywords: sialylmimetics, sialic acids, furane, molecular modeling, antiviral agents, neuraminidase inhibitor

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Letters in Organic Chemistry

Title: Design and Synthesis of a New Furanosic Sialylmimetic as a Potential Influenza Neuraminidase Viral Inhibitor

Volume: 2 Issue: 1

Author(s): A. Bianco, M. Brufani, D. A. Dri, C. Melchioni and L. Filocamo

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Keywords: sialylmimetics, sialic acids, furane, molecular modeling, antiviral agents, neuraminidase inhibitor

Abstract: A furanosic derivative has been identified as a simple sialylmimetic and synthesized, representing the first step in the development of a new series of furanosic sialic acids mimetics as potential inhibitors of influenza virus neuraminidase. The structure was tested on a molecular simulating environment before proceeding with synthetic pathways.

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Bianco A., Brufani M., Dri A. D., Melchioni C. and Filocamo L., Design and Synthesis of a New Furanosic Sialylmimetic as a Potential Influenza Neuraminidase Viral Inhibitor, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400207