Reaction Systems Peripheral to the 1:2 Mannich Condensation Reaction between o-Phthalaldehyde and Primary Amine

I.      Takahashi; K.      Nishiuchi; R.      Miyamoto; M.      Hatanaka; H.      Uchida; K.      Isa; A.      Sakushima; S.      Hosoi

doi:10.2174/1570178053400216

Abstract

Reaction systems peripheral to the 1:2 condensation reaction between o-phthalaldehyde and primary amine were studied. Newly identified were 1,3-dihydroxyisoindoline, o-iminomethylbenzaldehyde and oamidiniobenzoate, the last of which exhibited moderate anticancer activity.

Keywords: 1,3-dihydroxyisoindoline, o-iminomethylbenzaldehyde, o-amidiniobenzoate, anticancer activity

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Letters in Organic Chemistry

Title: Reaction Systems Peripheral to the 1:2 Mannich Condensation Reaction between o-Phthalaldehyde and Primary Amine

Volume: 2 Issue: 1

Author(s): I. Takahashi, K. Nishiuchi, R. Miyamoto, M. Hatanaka, H. Uchida, K. Isa, A. Sakushima and S. Hosoi

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Keywords: 1,3-dihydroxyisoindoline, o-iminomethylbenzaldehyde, o-amidiniobenzoate, anticancer activity

Abstract: Reaction systems peripheral to the 1:2 condensation reaction between o-phthalaldehyde and primary amine were studied. Newly identified were 1,3-dihydroxyisoindoline, o-iminomethylbenzaldehyde and oamidiniobenzoate, the last of which exhibited moderate anticancer activity.

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Takahashi I., Nishiuchi K., Miyamoto R., Hatanaka M., Uchida H., Isa K., Sakushima A. and Hosoi S., Reaction Systems Peripheral to the 1:2 Mannich Condensation Reaction between o-Phthalaldehyde and Primary Amine, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400216