A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines

Timothy   P.   Curran; Kevin   A.   Marques; Segufta   I.   Bilimoria

doi:10.2174/1570178053400063

Abstract

Reaction of 1 equivalent of N-“-acetyl-cis-4-azido-L-proline with 1 equivalent of an aldehyde and a catalytic amount of Pd-C under an H2 atmosphere cleanly and efficiently yields the corresponding N-“-acetylcis- 4-(N-γ-alkylamino)-L-proline derivative.

Keywords: aminoproline, reductive amination, azide, aldehyde, secondary amine

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Letters in Organic Chemistry

Title: A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines

Volume: 2 Issue: 1

Author(s): Timothy P. Curran, Kevin A. Marques and Segufta I. Bilimoria

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Keywords: aminoproline, reductive amination, azide, aldehyde, secondary amine

Abstract: Reaction of 1 equivalent of N-“-acetyl-cis-4-azido-L-proline with 1 equivalent of an aldehyde and a catalytic amount of Pd-C under an H2 atmosphere cleanly and efficiently yields the corresponding N-“-acetylcis- 4-(N-γ-alkylamino)-L-proline derivative.

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Curran P. Timothy, Marques A. Kevin and Bilimoria I. Segufta, A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400063