Role of Endogenous Cannabinoids in Cognition and Emotionality

Carsten   T.   Wotjak

doi:10.2174/1389557054368763

Abstract

Novel pharmacological tools and the generation of null-mutants enabled the elucidation of the role of endocannabinoids in cognition and emotionality of rats and mice. Endocannabinoids seem to limit memory retention, to facilitate memory extinction and to ensure adequate coping with stressful situations. A selective potentiation of these actions may lead to novel pharmacotherapies for human anxiety disorders.

Keywords: learning, memory, review, anxiety, fear, stress, faah, cb, trpv, vr

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Mini-Reviews in Medicinal Chemistry

Title: Role of Endogenous Cannabinoids in Cognition and Emotionality

Volume: 5 Issue: 7

Author(s): Carsten T. Wotjak

Affiliation:

Keywords: learning, memory, review, anxiety, fear, stress, faah, cb, trpv, vr

Abstract: Novel pharmacological tools and the generation of null-mutants enabled the elucidation of the role of endocannabinoids in cognition and emotionality of rats and mice. Endocannabinoids seem to limit memory retention, to facilitate memory extinction and to ensure adequate coping with stressful situations. A selective potentiation of these actions may lead to novel pharmacotherapies for human anxiety disorders.

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Wotjak T. Carsten, Role of Endogenous Cannabinoids in Cognition and Emotionality, Mini-Reviews in Medicinal Chemistry 2005; 5 (7) . https://dx.doi.org/10.2174/1389557054368763