Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation

Title: Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation

Volume: 5 Issue: 6

Author(s): Gerd Bendas

Affiliation:

Keywords: adhesion molecules, autoimmune disease, endothelium, inflammation, integrins, leukocytes, selectins

Abstract: The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.

Cite this article as:

Bendas Gerd, Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation, Mini-Reviews in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1389557054023279