Allosteric Modulation of Dopamine Receptors

John   A.   Schetz

doi:10.2174/1389557054023260

Abstract

Allosteric modulators allow for the fine-tuning of receptor responses to endogenous neurotransmitters and exogenous therapeutic agents. Different types of allosteric modulation of dopamine receptors are discussed as well as the significance of such modulation in the control of normal biological processes and in the treatment of disease.

Keywords: conformational change, regulation, modulate, plateau, catecholamine, biogenic amine, g protein-coupled receptor (gpcr), metal

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Mini-Reviews in Medicinal Chemistry

Title: Allosteric Modulation of Dopamine Receptors

Volume: 5 Issue: 6

Author(s): John A. Schetz

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Keywords: conformational change, regulation, modulate, plateau, catecholamine, biogenic amine, g protein-coupled receptor (gpcr), metal

Abstract: Allosteric modulators allow for the fine-tuning of receptor responses to endogenous neurotransmitters and exogenous therapeutic agents. Different types of allosteric modulation of dopamine receptors are discussed as well as the significance of such modulation in the control of normal biological processes and in the treatment of disease.

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Schetz A. John, Allosteric Modulation of Dopamine Receptors, Mini-Reviews in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1389557054023260