Mitochondrial Therapy: New Strategy in Preventing Oxidant-Induced Lung Injury

Yuchi      Li; Yuko      Arita; Jeffrey   A.   Kazzaz

doi:10.2174/1573398054023082

Abstract

Enhanced mitochondrial oxidative damage has been implicated in pathogenesis of various human diseases. This mini review will discuss the role of mitochondria in oxidative lung injury and the pathways induced by oxidant signaling. Recent studies suggest that mitochondrial targeting of antioxidants can reduce oxidant signaling and oxidant-stress while preserving mitochondrial structure and function. The impact on the treatment and prevention of acute lung injury will also be discussed.

Keywords: hyperoxia, ros, mitochondria, antioxidant enzyme, cell death, jnk pathways

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Current Respiratory Medicine Reviews

Title: Mitochondrial Therapy: New Strategy in Preventing Oxidant-Induced Lung Injury

Volume: 1 Issue: 2

Author(s): Yuchi Li, Yuko Arita and Jeffrey A. Kazzaz

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Keywords: hyperoxia, ros, mitochondria, antioxidant enzyme, cell death, jnk pathways

Abstract: Enhanced mitochondrial oxidative damage has been implicated in pathogenesis of various human diseases. This mini review will discuss the role of mitochondria in oxidative lung injury and the pathways induced by oxidant signaling. Recent studies suggest that mitochondrial targeting of antioxidants can reduce oxidant signaling and oxidant-stress while preserving mitochondrial structure and function. The impact on the treatment and prevention of acute lung injury will also be discussed.

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Li Yuchi, Arita Yuko and Kazzaz A. Jeffrey, Mitochondrial Therapy: New Strategy in Preventing Oxidant-Induced Lung Injury, Current Respiratory Medicine Reviews 2005; 1 (2) . https://dx.doi.org/10.2174/1573398054023082