AMPA Receptor Antagonists as Potential Anticonvulsant Drugs

Title: AMPA Receptor Antagonists as Potential Anticonvulsant Drugs

Volume: 5 Issue: 1

Author(s): Giovambattista De Sarro, Rosaria Gitto, Emilio Russo, Guido Ferreri Ibbadu, Maria Letizia Barreca, Laura De Luca and Alba Chimirri

Affiliation:

Keywords: glutamate, ampa receptor antagonists, ampar, anticonvulsants

Abstract: Over the last years α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological processes. Efforts targeting AMPAR have been focused on identification of ligands as potential therapeutic agents useful in the prevention and treatment of a variety of neurological and non-neurological diseases. In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents.

Cite this article as:

Sarro De Giovambattista, Gitto Rosaria, Russo Emilio, Ibbadu Ferreri Guido, Barreca Letizia Maria, Luca De Laura and Chimirri Alba, AMPA Receptor Antagonists as Potential Anticonvulsant Drugs, Current Topics in Medicinal Chemistry 2005; 5 (1) . https://dx.doi.org/10.2174/1568026053386999