Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines

S.   El   Kazzouli; A.      Berthault; S.      Berteina-Raboin; A.      Mouaddib; G.      Guillaumet

doi:10.2174/1570178053203017

Abstract

The Sonogashira cross-coupling with terminal alkynes and Buchwald coupling with aliphatic alcohols in position 6 of 2-phenylimidazo[1,2-a]pyridines was described. The position 3 was functionalized with various terminal alkynes in solution and on solid support to synthesize 3-substituted imidazo[1,2- a]pyridine derivatives.

Keywords: alkynes, 2-bromoacetophenone, copper-catalyzed coupling, cross-coupling reaction, pyridine, Iodination, palladium-coupling catalysis

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Letters in Organic Chemistry

Title: Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines

Volume: 2 Issue: 2

Author(s): S. El Kazzouli, A. Berthault, S. Berteina-Raboin, A. Mouaddib and G. Guillaumet

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Keywords: alkynes, 2-bromoacetophenone, copper-catalyzed coupling, cross-coupling reaction, pyridine, Iodination, palladium-coupling catalysis

Abstract: The Sonogashira cross-coupling with terminal alkynes and Buchwald coupling with aliphatic alcohols in position 6 of 2-phenylimidazo[1,2-a]pyridines was described. The position 3 was functionalized with various terminal alkynes in solution and on solid support to synthesize 3-substituted imidazo[1,2- a]pyridine derivatives.

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Kazzouli El S., Berthault A., Berteina-Raboin S., Mouaddib A. and Guillaumet G., Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines, Letters in Organic Chemistry 2005; 2 (2) . https://dx.doi.org/10.2174/1570178053203017