1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity

A.      Masuyama; J.-   M.   Wu; M.      Nojima; H.-   S.   Kim; Y.      Wataya

doi:10.2174/138955705774575255

Abstract

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Keywords: 1,2,4,5-tetraoxacycloalkanes, 1,2,5,6-tetraoxacycloalkanes, 1,2,6,7-tetraoxaspiro[7.11]nonadecane, antimalarial activity, medium-sized cyclic peroxides, cyclization methods, p. falciparum, p. berghei

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Mini-Reviews in Medicinal Chemistry

Title: 1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity

Volume: 5 Issue: 11

Author(s): A. Masuyama, J.- M. Wu, M. Nojima, H.- S. Kim and Y. Wataya

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Abstract: In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

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Masuyama A., Wu M. J.-, Nojima M., Kim S. H.- and Wataya Y., 1,2,4,5-Tetraoxacycloalkanes: Synthesis and Antimalarial Activity, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575255