Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

Title: Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review

Volume: 5 Issue: 11

Author(s): Thomas Scior, Antonio Guevara-Garcia, Philippe Bernard, Quoc-Tuan Do, David Domeyer and Stefan Laufer

Affiliation:

Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design

Abstract: Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.

Cite this article as:

Scior Thomas, Guevara-Garcia Antonio, Bernard Philippe, Do Quoc-Tuan, Domeyer David and Laufer Stefan, Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575264