Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents

Title: Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents

Volume: 1 Issue: 1

Author(s): Z. Guo, S. Vangapandu, A. Nimrod, L. A. Walker and R. D. Sindelar

Affiliation:

Keywords: bruceantin, partial analogs, bioassay, structure activity relationships, antileukemic and antimalarial activities

Abstract: Bruceantin (1), a classical quassinoid with the highest reported antimalarial activity among the quassinoids examined thus far, was selected as a natural product lead for the design of a series of A/B-ring analogs. A viable strategy for the synthesis of the series was developed. The functionalized A-ring and the C-15 ester moiety in bruceantin are incorporated in all designed compounds. The preliminary bioassay results will be discussed in detail.

Cite this article as:

Guo Z., Vangapandu S., Nimrod A., Walker A. L. and Sindelar D. R., Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents, Medicinal Chemistry 2005; 1 (1) . https://dx.doi.org/10.2174/1573406053402488