Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues

S.   A.   Kotharkar; M.   R.   Jadhav; R.   R.   Nagawade; S.   S.   Bahekar; D.   B.   Shinde

doi:10.2174/157017805774296830

Abstract

The substituted 3,4-dihydropyrimidin-2(1H)-ones and their thione analogues have been prepared Via Biginelli condensation using aldehyde, 1,3-dicarbonyl compound and urea or thiourea under the catalyst of sulphamic acid (H2NSO3H). The method is simple, cost-effective, and gives good yields in a shorter reaction time.

Keywords: sulphamic acid, catalyst, biginelli reaction

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Letters in Organic Chemistry

Title: Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues

Volume: 2 Issue: 7

Author(s): S. A. Kotharkar, M. R. Jadhav, R. R. Nagawade, S. S. Bahekar and D. B. Shinde

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Keywords: sulphamic acid, catalyst, biginelli reaction

Abstract: The substituted 3,4-dihydropyrimidin-2(1H)-ones and their thione analogues have been prepared Via Biginelli condensation using aldehyde, 1,3-dicarbonyl compound and urea or thiourea under the catalyst of sulphamic acid (H2NSO3H). The method is simple, cost-effective, and gives good yields in a shorter reaction time.

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Kotharkar A. S., Jadhav R. M., Nagawade R. R., Bahekar S. S. and Shinde B. D., Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues, Letters in Organic Chemistry 2005; 2 (7) . https://dx.doi.org/10.2174/157017805774296830