Synthesis of 2,3,4-Trisubstituted Chromans Via Nucleophilic Addition of N-, C-, and SNucleophiles to 3-Nitro-2-Trihalomethyl-2H-Chromenes. Stereochemical and Conformational Preferences

Title: Synthesis of 2,3,4-Trisubstituted Chromans Via Nucleophilic Addition of N-, C-, and SNucleophiles to 3-Nitro-2-Trihalomethyl-2H-Chromenes. Stereochemical and Conformational Preferences

Volume: 2 Issue: 7

Author(s): V. Y. Korotaev, V. Y. Sosnovskikh, I. B. Kutyashev and M. I. Kodess

Affiliation:

Keywords: nitro- h-chromenes, s-nucleophiles, nucleophilic addition, trisubstituted chromans

Abstract: Reactions of N-, C-, and S-nucleophiles with 3-nitro-2-trifluoro(or trichloro)methyl-2H-chromenes proceeded via nucleophilic addition at the double bond to give 2,3,4-trisubstituted chromans in good to moderate yields. Stereochemical and conformational preferences of 2,3,4-trisubstituted chromans were studied.

Cite this article as:

Korotaev Y. V., Sosnovskikh Y. V., Kutyashev B. I. and Kodess I. M., Synthesis of 2,3,4-Trisubstituted Chromans Via Nucleophilic Addition of N-, C-, and SNucleophiles to 3-Nitro-2-Trihalomethyl-2H-Chromenes. Stereochemical and Conformational Preferences, Letters in Organic Chemistry 2005; 2 (7) . https://dx.doi.org/10.2174/157017805774297000