Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases

Title: Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases

Volume: 12 Issue: 3

Author(s): Carlos H.I. Ramos and Sergio T. Ferreira

Affiliation:

Keywords: protein folding, misfolding, aggregation, amyloid, amyloidoses

Abstract: Proteins carry out many vital cellular functions determined by their precise 3-dimensional structures (the native conformations). Understanding how proteins fold has long been a major goal and can be of great therapeutic value. Failure to reach or maintain the correct folded structure can have serious consequences, as in the conformational diseases. The ultimate goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of aberrant disease-associated conformations.

Cite this article as:

Ramos H.I. Carlos and Ferreira T. Sergio, Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases, Protein & Peptide Letters 2005; 12 (3) . https://dx.doi.org/10.2174/0929866053587156