Retinoids as Therapeutic Agents: Today and Tomorrow

Valerie      Vivat-Hannah; F.   Christopher   Zusi

doi:10.2174/1389557054553820

Abstract

Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.

Keywords: rar, rxr, transcription factors, cancer, skin, type II diabetes, retinoids, rexinoids