A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Title: A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Volume: 2 Issue: 4

Author(s): S. P. Gupta, Anitha Paleti, S. B. Mekapati, A. N. Nagappa and S. Kumaran

Affiliation:

Keywords: channel blockers, qsar, connectivity index

Abstract: A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and on a series of K+ channel blockers (blockers of cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, the blocking activity is found to be significantly correlated with Kiers first-order valence molecular connectivity index.

Cite this article as:

Gupta P. S., Paleti Anitha, Mekapati B. S., Nagappa N. A. and Kumaran S., A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038422

DOI https://dx.doi.org/10.2174/1570180054038422	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X