Synthesis of 2,3-Didehydro-2,3-dideoxynucleosides via Nucleoside Route.

Christophe      Len; Denis      Postel

doi:10.2174/157017906777934881

Abstract

2,3-Didehydro- and 2,3-dideoxynucleosides are both potent antiviral agents. In particular, they are Nucleoside Reverse Transcriptase Inhibitors and hence active against HIV, the ethiological agent of AIDS. They are also intermediates for the synthesis of antiviral 2,3-dideoxynucleosides. Various aspects of synthetic routes to 2,3-unsaturated nucleosides are reviewed with examples being chosen from work published between 1966 and 2003.

Keywords: reverse transcriptase (RT), Halogenoacetate, bromomesylate, deprotection, Eastwood reaction

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Current Organic Synthesis

Title: Synthesis of 2,3-Didehydro-2,3-dideoxynucleosides via Nucleoside Route.

Volume: 3 Issue: 3

Author(s): Christophe Len and Denis Postel

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Keywords: reverse transcriptase (RT), Halogenoacetate, bromomesylate, deprotection, Eastwood reaction

Abstract: 2,3-Didehydro- and 2,3-dideoxynucleosides are both potent antiviral agents. In particular, they are Nucleoside Reverse Transcriptase Inhibitors and hence active against HIV, the ethiological agent of AIDS. They are also intermediates for the synthesis of antiviral 2,3-dideoxynucleosides. Various aspects of synthetic routes to 2,3-unsaturated nucleosides are reviewed with examples being chosen from work published between 1966 and 2003.

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Len Christophe and Postel Denis, Synthesis of 2,3-Didehydro-2,3-dideoxynucleosides via Nucleoside Route., Current Organic Synthesis 2006; 3 (3) . https://dx.doi.org/10.2174/157017906777934881