Photoaffinity Labeling of P-Glycoprotein

Michael      Peer; Edina      Csaszar; Elisabeth      Vorlaufer; Stephan      Kopp; Peter      Chiba

doi:10.2174/1389557053402738

Abstract

The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.

Keywords: multidrug resistance, p-glycoprotein, affinity labeling

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Mini-Reviews in Medicinal Chemistry

Title: Photoaffinity Labeling of P-Glycoprotein

Volume: 5 Issue: 2

Author(s): Michael Peer, Edina Csaszar, Elisabeth Vorlaufer, Stephan Kopp and Peter Chiba

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Keywords: multidrug resistance, p-glycoprotein, affinity labeling

Abstract: The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.

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Peer Michael, Csaszar Edina, Vorlaufer Elisabeth, Kopp Stephan and Chiba Peter, Photoaffinity Labeling of P-Glycoprotein, Mini-Reviews in Medicinal Chemistry 2005; 5 (2) . https://dx.doi.org/10.2174/1389557053402738