Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?

Title: Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?

Volume: 5 Issue: 10

Author(s): Olaf Jahn, Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart and Joachim Spiess

Affiliation:

Keywords: corticotropin-releasing factor (crf), crf binding protein (crfbp), crfbp inhibitor, urocortin, cognitive deficits

Abstract: The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

Cite this article as:

Jahn Olaf, Radulovic Jelena, Stiedl Oliver, Tezval Hossein, Eckart Klaus and Spiess Joachim, Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?, Mini-Reviews in Medicinal Chemistry 2005; 5 (10) . https://dx.doi.org/10.2174/138955705774329500