Fluorinated Natural Products with Clinical Significance

Title: Fluorinated Natural Products with Clinical Significance

Volume: 6 Issue: 14

Author(s): Craig J. Thomas

Affiliation:

Keywords: Natural products, fluorine, camptothecin, artemisinin, Vinca alkaloids, taxanes, epothilones

Abstract: The modification of natural products in an effort to alter their biochemical capacity is a common technique utilized by synthetic and medicinal chemists. Fluorine substitution imparts unique and advantageous physiochemical properties that can be shrewdly employed to constructively alter pharmacological agents. The adornment of natural products with fluorine has proven beneficial in several examples. This overview discusses several of the most relevant fluorinated natural products under current examination.

Cite this article as:

Thomas J. Craig, Fluorinated Natural Products with Clinical Significance, Current Topics in Medicinal Chemistry 2006; 6 (14) . https://dx.doi.org/10.2174/156802606777951109