The Cannabinergic System as a Target for Anti-inflammatory Therapies

Title: The Cannabinergic System as a Target for Anti-inflammatory Therapies

Volume: 6 Issue: 13

Author(s): Dai Lu, V. Kiran Vemuri, Richard I. Duclos, Jr. and Alexandros Makriyannis

Affiliation:

Keywords: Cannabinoid, endocannabinoid system, anti-inflammation, immune modulation, inflammatory pain

Abstract: Habitual cannabis use has been shown to affect the human immune system, and recent advances in endocannabinoid research provide a basis for understanding these immunomodulatory effects. Cell-based experiments or in vivo animal testing suggest that regulation of the endocannabinoid circuitry can impact almost every major function associated with the immune system. These studies were assisted by the development of numerous novel molecules that exert their biological effects through the endocannabinoid system. Several of these compounds were tested for their effects on immune function, and the results suggest therapeutic opportunities for a variety of inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, allergic asthma, and autoimmune diabetes through modulation of the endocannabinoid system.

Cite this article as:

Lu Dai, Kiran Vemuri V., Duclos I. Richard, Jr. and Makriyannis Alexandros, The Cannabinergic System as a Target for Anti-inflammatory Therapies, Current Topics in Medicinal Chemistry 2006; 6 (13) . https://dx.doi.org/10.2174/15680266106061401