Analysis of Monomeric Mutants of HSC70: A Possible Relationship Between Oligomerization and Functional Properties

Mouna Amor-Mahjoub; Nathalie Gomez-Vrielyunck; Jean Philippe Suppini; Benoit Fouchaq; Nadia Benaroudj; Moncef Ladjimi

doi:10.2174/092986607781483624

Abstract

Data of this study showed that αD-αE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.

Keywords: HSC70, Mutagenesis, Oligomerization, Ultracentrifugation, ATPase activity

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Protein & Peptide Letters

Title: Analysis of Monomeric Mutants of HSC70: A Possible Relationship Between Oligomerization and Functional Properties

Volume: 14 Issue: 8

Author(s): Mouna Amor-Mahjoub, Nathalie Gomez-Vrielyunck, Jean Philippe Suppini, Benoit Fouchaq, Nadia Benaroudj and Moncef Ladjimi

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Keywords: HSC70, Mutagenesis, Oligomerization, Ultracentrifugation, ATPase activity

Abstract: Data of this study showed that αD-αE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins.

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Mouna Amor-Mahjoub , Nathalie Gomez-Vrielyunck , Jean Philippe Suppini , Benoit Fouchaq , Nadia Benaroudj and Moncef Ladjimi , Analysis of Monomeric Mutants of HSC70: A Possible Relationship Between Oligomerization and Functional Properties, Protein & Peptide Letters 2007; 14 (8) . https://dx.doi.org/10.2174/092986607781483624