α-Methylated Polyamines as Potential Drugs and Experimental Tools in Enzymology

Title: α-Methylated Polyamines as Potential Drugs and Experimental Tools in Enzymology

Volume: 7 Issue: 8

Author(s): Tuomo A. Keinanen, Aki Jarvinen, Anne Uimari, Jouko Vepsalainen, Alex R. Khomutov, Nikolay A. Grigorenko, Mervi T. Hyvonen, Marc Cerrada-Gimenez, Leena Alhonen and Juhani Janne

Affiliation:

Keywords: Hypusine, liver regeneration, pancreatitis, polyamine oxidase, spermidine/spermine N1-acetyltransferase, stereospecificity, transgenic

Abstract: We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.

Cite this article as:

Tuomo A. Keinanen , Aki Jarvinen , Anne Uimari , Jouko Vepsalainen , Alex R. Khomutov , Nikolay A. Grigorenko , Mervi T. Hyvonen , Marc Cerrada-Gimenez , Leena Alhonen and Juhani Janne , α-Methylated Polyamines as Potential Drugs and Experimental Tools in Enzymology, Mini-Reviews in Medicinal Chemistry 2007; 7 (8) . https://dx.doi.org/10.2174/138955707781387867