Microwave Accelerated Multicomponent Synthesis for a Novel Scaffold of Monastrol Analogues

Mazaahir Kidwai; Suchi Kukreja; Shewta Rastogi; Kavita Singhal

doi:10.2174/157017807781212085

Abstract

A highly efficient and environmentally benign reaction of dimedone with various aldehydes and Narylthioureas to afford monastrol analogues is revealed. The reaction is found to be sensitive towards the steric and electronic effects of the substituents in variable components. A quantitative optimization of catalytic support is also presented.

Keywords: Monastrol, microwaves, multicomponent reactions, electronic and steric effects

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Letters in Organic Chemistry

Title: Microwave Accelerated Multicomponent Synthesis for a Novel Scaffold of Monastrol Analogues

Volume: 4 Issue: 5

Author(s): Mazaahir Kidwai, Suchi Kukreja, Shewta Rastogi and Kavita Singhal

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Keywords: Monastrol, microwaves, multicomponent reactions, electronic and steric effects

Abstract: A highly efficient and environmentally benign reaction of dimedone with various aldehydes and Narylthioureas to afford monastrol analogues is revealed. The reaction is found to be sensitive towards the steric and electronic effects of the substituents in variable components. A quantitative optimization of catalytic support is also presented.

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Mazaahir Kidwai , Suchi Kukreja , Shewta Rastogi and Kavita Singhal , Microwave Accelerated Multicomponent Synthesis for a Novel Scaffold of Monastrol Analogues, Letters in Organic Chemistry 2007; 4 (5) . https://dx.doi.org/10.2174/157017807781212085