Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors

Title: Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors

Volume: 7 Issue: 7

Author(s): Seiichiro Ogawa, Miki Kanto, Yoshiyuki Suzuki, Seiichiro Ogawa, Miki Kanto and Yoshiyuki Suzuki

Affiliation:

Keywords: Carbasugars, aminocyclitols, 5a-carbaglycosylamines, glycosidase inhibitors, chemical chaperone therapy, lysosomal disease, GM1-gangliosidosis

Abstract: This article reviews synthesis and structures of carbaglycosylamines, a group of carbocyclic sugar analogues. Some unsaturated derivatives are known to be potent glycosidase inhibitors. Among them, N-octyl-4-epi-??-valienamine as a lysosomal ??-galactosidase inhibitor is currently undergoing a new molecular therapeutic trial (chemical chaperone therapy) for control of the human ??-galactosidase deficiency disorder, GM1-gangliosidosis.

Cite this article as:

Seiichiro Ogawa , Miki Kanto , Yoshiyuki Suzuki , Ogawa Seiichiro, Kanto Miki and Suzuki Yoshiyuki, Development and Medical Application of Unsaturated Carbaglycosylamine Glycosidase Inhibitors, Mini-Reviews in Medicinal Chemistry 2007; 7 (7) . https://dx.doi.org/10.2174/138955707781024508