Lipase Catalysed Kinetic Resolution of 2-Nitroalcohol: Total Synthesis of Taxol Side Chain and (-)-Bestatin

Naminita Gogoi; Jagat C. Borah; Joshodeep Boruwa; Nabin C. Barua

doi:10.2174/157017807781024192

Abstract

2-Nitroalcohols were efficiently resolved by Lipase catalysed transesterification process. This protocol was successfully applied to the synthesis of taxol side chain and (-)-bestatin in overall yields of 40% and 20% respectively.

Keywords: Taxol Side Chain, (-)-Bestatin, lipase catalysed kinetic resolution

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Letters in Organic Chemistry

Title: Lipase Catalysed Kinetic Resolution of 2-Nitroalcohol: Total Synthesis of Taxol Side Chain and (-)-Bestatin

Volume: 4 Issue: 4

Author(s): Naminita Gogoi, Jagat C. Borah, Joshodeep Boruwa and Nabin C. Barua

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Keywords: Taxol Side Chain, (-)-Bestatin, lipase catalysed kinetic resolution

Abstract: 2-Nitroalcohols were efficiently resolved by Lipase catalysed transesterification process. This protocol was successfully applied to the synthesis of taxol side chain and (-)-bestatin in overall yields of 40% and 20% respectively.

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Naminita Gogoi , Jagat C. Borah , Joshodeep Boruwa and Nabin C. Barua , Lipase Catalysed Kinetic Resolution of 2-Nitroalcohol: Total Synthesis of Taxol Side Chain and (-)-Bestatin, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024192