Small Molecule Ligands of the Human Melanocortin-4 Receptor

Title: Small Molecule Ligands of the Human Melanocortin-4 Receptor

Volume: 7 Issue: 11

Author(s): Feroze Ujjainwalla and Iyassu K. Sebhat

Affiliation:

Keywords: Computational modeling, cytochrome P450 3A4 isozyme, Piperidine, G-protein coupled receptors, MC4R Agonists

Abstract: Genetic and pharmacological studies, involving both animals and humans, suggest that the central MC4 receptor plays a key role in homeostatic control, most probably via regulation of appetite and energy expenditure. This has stimulated intense research efforts in the field of drug discovery to identify MC4 receptor agonists and antagonists for the therapeutic treatment of obesity and diseases associated with loss of body weight. This article constitutes a near comprehensive review of the published scientific literature on small molecule ligands of the hMC4 receptor since 2002.

Cite this article as:

Feroze Ujjainwalla and Iyassu K. Sebhat , Small Molecule Ligands of the Human Melanocortin-4 Receptor, Current Topics in Medicinal Chemistry 2007; 7 (11) . https://dx.doi.org/10.2174/156802607780906609