A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins

Title: A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins

Volume: 7 Issue: 6

Author(s): Joseph Markowitz, Alexander D. MacKerell and David J. Weber

Affiliation:

Keywords: S100B, p53, calcium, inhibitors, drug design, cancer

Abstract: Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.

Cite this article as:

Joseph Markowitz , Alexander D. MacKerell and David J. Weber , A Search for Inhibitors of S100B, a Member of the S100 Family of Calcium-Binding Proteins, Mini-Reviews in Medicinal Chemistry 2007; 7 (6) . https://dx.doi.org/10.2174/138955707780859422