Identification of Immunogenic MHC Class II Tyrosinase-Derived Peptides Using HLA-DR1 and HLA-DR4 Transgenic Mice

Title: Identification of Immunogenic MHC Class II Tyrosinase-Derived Peptides Using HLA-DR1 and HLA-DR4 Transgenic Mice

Volume: 14 Issue: 5

Author(s): R. B.V. Horton, S. A.S. Laversin, S. P. Reeder, R. C. Rees and S. E.B. McArdle

Affiliation:

Keywords: mhc class, peptides, cd t cells, vitamin e, dendritic cells

Abstract: The immunogenicity of “novel” MART-1 and Tyrosinase class-II peptides was assessed in transgenic mice. Tyrosinase141-161 peptide was found to be immunogenic and endogenously processed in the HLA-DRβ1*0101 and HLADR β1*0401 transgenic mice with peptide specific production of IFNγ or IL-5 respectively. The MART-129-43 peptide was only found immunogenic in HLA-DRβ1*0101 mice.

Cite this article as:

Horton B.V. R., Laversin A.S. S., Reeder P. S., Rees C. R. and McArdle E.B. S., Identification of Immunogenic MHC Class II Tyrosinase-Derived Peptides Using HLA-DR1 and HLA-DR4 Transgenic Mice, Protein & Peptide Letters 2007; 14 (5) . https://dx.doi.org/10.2174/092986607780782768